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Vetoryl

Vetoryl Hard Capsules for Dogs are indicated for the treatment of pituitary-dependant hyperadrenocorticism in dogs and the treatment of hyperadrenocorticism due to adrenocortical tumour in dogs. They contain Trilostane which selectively and reversibly inhibits the enzyme system involved in the synthesis of several steroids including cortisol and aldosterone.

Vetoryl are supplied as hard capsules with an ivory body and black cap. The capsule strength is printed on the body of the capsule.

Vetoryl 10mg Hard Capsules for Dogs

Vetoryl 10mg Hard Capsules for Dogs

£1.38

Vetoryl 10mg Hard Capsules for Dogs are indicated for the treatment of pituitary-dependant and adrenal-dependent hyperadrenocorticism (Cushing’s disease and syndrome). The active...[More info]

£1.38
Vetoryl 30mg Hard Capsules for Dogs

Vetoryl 30mg Hard Capsules for Dogs

£1.73

Vetoryl 30mg Hard Capsules for Dogs are indicated for the treatment of pituitary-dependant and adrenal-dependent hyperadrenocorticism (Cushing’s disease and syndrome). The active...[More info]

£1.73
Vetoryl 60mg Hard Capsules for Dogs

Vetoryl 60mg Hard Capsules for Dogs

£2.15

Vetoryl 60mg Hard Capsules for Dogs are indicated for the treatment of pituitary-dependant and adrenal-dependent hyperadrenocorticism (Cushing’s disease and syndrome). The active...[More info]

£2.15
Vetoryl 120mg Hard Capsules for Dogs

Vetoryl 120mg Hard Capsules for Dogs

£3.46

Vetoryl 120mg Hard Capsules for Dogs are indicated for the treatment of pituitary-dependant and adrenal-dependent hyperadrenocorticism (Cushing’s disease and syndrome). The active...[More info]

£3.46

Contraindications
Vetoryl 10 mg hard capsules for dogs: Do not use in dogs weighing less than 3 kg.
Vetoryl 30 mg hard capsules for dogs: Do not use in dogs weighing less than 3 kg.
Vetoryl 60 mg hard capsules for dogs: Do not use in dogs weighing less than 10 kg.
Vetoryl 120 mg hard capsules for dogs: Do not use in dogs weighing less than 20 kg.
Do not use in animals suffering from primary hepatic disease and/or renal insufficiency.
Do not use where there is suspected hypersensitivity to the active substance or to any of the excipients.

Special warnings for each target species
An accurate diagnosis of hyperadrenocorticism is essential.
Where there is no apparent response to treatment, the diagnosis should be re-evaluated. Dose increases may be necessary.
Veterinarians should be aware that dogs with hyperadrenocorticism are at increased risk of pancreatitis. This risk may not diminish following treatment with trilostane.

Special precautions for use in animals
As the majority of cases of hyperadrenocorticism are diagnosed in dogs between the ages of 10-15 years, other pathological processes are frequently present. It is particularly important to screen cases for primary hepatic disease and renal insufficiency as the product is contraindicated in these cases.
Subsequent close monitoring during treatment should be carried out. Particular attention should be paid to liver enzymes, electrolytes, urea and creatinine.
The presence of diabetes mellitus and hyperadrenocorticism together requires specific monitoring.
If a dog has previously been treated with mitotane, its adrenal function will have been reduced. Experience in the field suggests that an interval of at least a month should elapse between cessation of mitotane and the introduction of trilostane. Close monitoring of adrenal function is advised, as dogs may be more susceptible to the effects of trilostane.
The product should be used with extreme caution in dogs with pre-existing anaemia as further reductions in packed-cell volume and haemoglobin may occur. Regular monitoring should be undertaken.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Trilostane may decrease testosterone synthesis and has anti-progesterone properties. Women who are pregnant or are intending to become pregnant should avoid handling the capsules.
Wash hands with soap and water following accidental exposure and after use.
The content of the capsules may cause skin and eye irritation and sensitisation. Do not divide or open capsules: in the event of accidental breakage of the capsules and contact of the granules with eyes or skin, wash immediately with plenty of water. If irritation persists, seek medical advice.
People with known hypersensitivity to trilostane or any of the excipients should avoid contact with the product.
In the event of accidental ingestion, seek medical advice immediately and show the package leaflet or carton to the physician.

Adverse reactions
Corticosteroid withdrawal syndrome or hypocortisolaemia should be distinguished from hypoadrenocorticism by evaluation of serum electrolytes.
Signs associated with iatrogenic hypoadrenocorticism, including weakness, lethargy, anorexia, vomiting and diarrhoea may occur, particularly if monitoring is not adequate (see Amounts to be administered and administration route). Signs are generally reversible within a variable period following withdrawal of treatment. Acute Addisonian crisis (collapse) may also occur (see Overdose). Lethargy, vomiting, diarrhoea and anorexia have been seen in dogs treated with trilostane in the absence of evidence of hypoadrenocorticism.
There have been occasional isolated reports of adrenal necrosis in treated dogs which may result in hypoadrenocorticism.
Subclinical renal dysfunction may be unmasked by treatment with the product.
Treatment may unmask arthritis due to a reduction in endogenous corticosteroid levels.
A small number of reports have been received of sudden death during treatment.
Other mild, rare, adverse effects include ataxia, hypersalivation, bloating, muscle tremors and skin changes.

Use during pregnancy and lactation
Do not use in pregnant or lactating bitches or in any animals intended for breeding.

Interactions
The possibility of interactions with other medicinal products has not been specifically studied. Given that hyperadrenocorticism tends to occur in older dogs, many will be receiving concurrent medication. In clinical studies, no interactions were observed.
The risk of hyperkalaemia developing should be considered if trilostane is used in conjunction with potassium-sparing diuretics or ACE inhibitors. The concurrent use of such drugs should be subject to a risk/benefit analysis by the veterinary surgeon, as there have been a few reports of deaths (including sudden death) in dogs when treated concurrently with trilostane and an ACE inhibitor.

Amounts to be administered and administration route
Administer orally, once daily, with food. The starting dose for treatment is approximately 2 mg/kg, based on available combinations of capsule sizes. Titrate the dose according to individual response, as determined by monitoring (see below). If a dose increase is required, use combinations of capsule sizes to slowly increase the once daily dose. A wide range of capsule sizes enables optimum dosing for the individual dog. Administer the lowest dose necessary to control the clinical signs.
Ultimately, if symptoms are not adequately controlled for an entire 24 hour inter-dose period, consider increasing the total daily dose by up to 50% and dividing it equally between morning and evening doses.
Do not divide or open capsules.
A small number of animals may require doses significantly in excess of 10 mg per kg body weight per day. In these situations appropriate additional monitoring should be implemented.
Monitoring: Samples should be taken for biochemistry (including electrolytes) and an ACTH stimulation test pre-treatment and then at 10 days, 4 weeks, 12 weeks, and thereafter every 3 months, following initial diagnosis and after each dose adjustment. It is imperative that ACTH stimulation tests are performed 4-6 hours post-dosing to enable accurate interpretation of results.
Dosing in the morning is preferable as this will allow your veterinary surgeon to perform monitoring tests 4-6 hours following administration of the dose. Regular assessment of the clinical progress of the disease should also be made at each of the above time points.
In the event of a non-stimulatory ACTH stimulation test during monitoring, treatment should be stopped for 7 days and then re-started at a lower dose. Repeat the ACTH stimulation test after a further 14 days. If the result is still non-stimulatory, stop treatment until clinical signs of hyperadrenocorticism recur. Repeat the ACTH stimulation test one month after re-starting treatment.

Overdose
Overdose may lead to signs of hypoadrenocorticism (lethargy, anorexia, vomiting, diarrhoea, cardiovascular signs, collapse). There were no mortalities following chronic administration at 36mg/kg to healthy dogs, however mortalities may be expected if higher doses are administered to dogs with hyperadrenocorticism.
There is no specific antidote for trilostane. Treatment should be withdrawn and supportive therapy, including corticosteroids, correction of electrolyte imbalances and fluid therapy may be indicated depending on the clinical signs.
In cases of acute overdosage, induction of emesis followed by administration of activated charcoal may be beneficial.
Any iatrogenic adrenocortical insufficiency is usually quickly reversed following cessation of treatment. However in a small percentage of dogs, effects may be prolonged. Following a one week withdrawal of trilostane treatment, treatment should be reinstated at a reduced dose rate.