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Frontline Combo

Frontline Combo has been developed for the treatment of flea infestations on cats, dogs and ferrets, alone or in association with ticks. The spot-on solution works against new infestations of adult fleas for up to 4 weeks in cats and ferrets, and for up to 8 weeks on dogs, as well as inhibiting the development of eggs, larvae and pupae originating from eggs laid by adult fleas.

Frontline Combo also has a persistent acaricidal efficacy against ticks for up to 2 weeks in cats, and 4 weeks in ferrets and dogs.

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Frontline Combo Spot-On for Cats and Ferrets

Frontline Combo Spot-On for Cats and Ferrets

From:£9.13 to… £23.93

Frontline Combo Spot-On for Cats and Ferrets is indicated for the use against infestations with fleas, alone or in association with ticks and/or biting lice in cats, and against...[More info]

From:£9.13 to… £23.93
Frontline Combo Spot-On for Large Dogs

Frontline Combo Spot-On for Large Dogs

From:£19.57 to… £33.23

Frontline Combo Spot-On for Large Dogs is indicated to be used against infestations with fleas, alone or in association with ticks and/or biting lice on dogs weighing 20 – 40kg....[More info]

From:£19.57 to… £33.23
Frontline Combo Spot-On for Medium Dogs

Frontline Combo Spot-On for Medium Dogs

From:£18.10 to… £30.19

Frontline Combo Spot-On for Medium Dogs is indicated to be used against infestations with fleas, alone or in association with ticks and/or biting lice on dogs weighing 10 – 20kg....[More info]

From:£18.10 to… £30.19
Frontline Combo Spot-On for Small Dogs

Frontline Combo Spot-On for Small Dogs

From:£16.40 to… £28.00

Frontline Combo Spot-On for Small Dogs is indicated to be used against infestations with fleas, alone or in association with ticks and/or biting lice on dogs weighing 2 – 10kg....[More info]

From:£16.40 to… £28.00
Frontline Combo Spot-On for Extra Large Dogs

Frontline Combo Spot-On for Extra Large Dogs

From:£22.92 to… £38.92

Frontline Combo Spot-On for Extra Large Dogs is indicated to be used against infestations with fleas, alone or in association with ticks and/or biting lice on dogs weighing over 40kg....[More info]

From:£22.92 to… £38.92

Contra-indications
Cats and Ferrets: In the absence of available data, the product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. The product should not be used on ferrets less than 6 months old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits as adverse drug reactions, even mortality, could occur. In absence of studies, the use of the product is not recommended in non-target species.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Dogs: In the absence of available data, the product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse drug reactions, even mortality, could occur.
In absence of studies, the use of the product is not recommended in non-target species. This product is specifically developed for dogs. Do not use in cats and ferrets, as this could lead to overdosing.

Special warnings for each target species
Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study.
Dogs should not be allowed to swim in watercourses for 2 days after application. There may be an attachment of a few ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.
Avoid contact with the animal's eyes.
Other animals living in the same household should also be treated with a suitable product.

Special precautions for use in animals
Avoid contact with the animal's eyes. It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.
It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment. No data on the effect of bathing/shampooing on the efficacy of the product in cats and ferrets are available. However, based on information available for dogs shampooed from 2 days after application of the product, it is not recommended to bath animals within 2 days after application of the product.
There may be an attachment of single ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.
The potential toxicity of the product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case.

Special precautions to be taken by the person administering the product to animals
This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. Animals or operators with a known hypersensitivity to insecticides or alcohol should avoid contact with the product.
Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water. After accidental ocular exposure the eye should be rinsed carefully with pure water. Wash hands after use.
Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.
Do not smoke, drink or eat during application.

Adverse reactions
Among the very rare suspected reactions, transient skin reactions at the application site (skin discoloration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory symptoms have also been observed after use. If licking occurs, a brief period of excessive salivation may be observed due mainly to the nature of the carrier. Do not overdose.

Use during pregnancy, lactation or lay
Cats: The product can be used in cats during pregnancy, for treatment during the lactating period see 'Special precautions for use in animals'.
Dogs: The product can be used during pregnancy and lactation.
Ferrets: Laboratory studies in cats have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. The safety of the veterinary medicinal product has not been established in ferrets during pregnancy and lactation. Use only according to the risk-benefit assessment by the responsible veterinarian.

Interactions
None known.

Amounts to be administered and administration route
Cats: One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of 5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.
Dogs: By topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.
Ferrets: One pipette of 0.5 ml per ferret corresponding to a dose of 50 mg for fipronil and 60 mg for (S)-methoprene per ferret, by topical application to the skin. The minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.
Temporary changes to the coat (clumped/greasy hair) may be noted at the application site.

Overdose
Cats: No undesirable effects were observed in target animal safety studies in cats and kittens aged 8 weeks and older and weighing about 1 kg treated once a month at five times the recommended dose for six consecutive months. Itching may occur following treatment. Overdose application of the product will cause a sticky appearance of hairs at the treatment spot. However, should this occur, it will disappear within 24 hours post application.
Dogs: No adverse effects were observed in target animal safety studies in 8 week old puppies, growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of experiencing adverse effects may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.
Ferrets: In ferrets aged 6 months and older and treated once every 2 weeks for four treatments, at five times the recommended dose, body weight loss was observed in some animals.