Contraindications
Do not use in animals with renal insufficiency, diabetes mellitus or corneal ulceration.
Do not use in animals receiving vaccines containing live organisms.
Do not use in pregnant animals.

Special warnings for each target species
There are no special warnings required for either target species.

Special precautions for use in animals
Pharmacologically-active dose levels may lead to atrophy of the adrenal cortex, resulting in adrenal insufficiency. This may become apparent particularly after withdrawal of corticosteroid treatment.
Adrenal insufficiency may be minimised by institution of alternate-day therapy if practical. The dosage should be reduced and withdrawn gradually to avoid precipitation of adrenal insufficiency.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Gloves should be worn to administer the product and you should wash your hands immediately after administration of the product.
In the event of accidental ingestion, particularly by a child, seek medical advice and show the doctor the label or package leaflet.

Adverse reactions
Administration of single high doses are generally tolerated well, but medium to long-term use may provoke reactions.
Corticosteroid therapy may lead to increased time in the healing of wounds and to a reduction in the ability of the body to resist infection. Appropriate anti-infective therapy may be required.

Use during pregnancy and lactation
Corticosteroids are not recommended for use in pregnant animals. Studies in laboratory animals have shown that administration during early pregnancy may cause foetal abnormalities. Administration during the later stages of pregnancy may cause abortion or early parturition.
Insignificant amounts of prednisolone are generally eliminated in the milk of lactating animals, and therefore such use is not contraindicated.

Interactions
There are no known interactions of significance in veterinary medicine.

Amounts to be administered and administration route
For oral administration.
Dogs and cats: 0.1 - 2.0 mg per kg body weight per day.
A single administration may be sufficient for certain conditions such as anaphylaxis, but for more general treatment, treatment for one to three weeks at the above dosage levels may be required. Dosage levels should be monitored carefully to ensure that the lowest effective dose is used. To minimise the risk of adrenal insufficiency, alternate day treatment may be implemented, using dose levels that adequately control the symptoms. Dogs should be dosed in the morning and cats should be dosed at night to coincide with the endogenous cortisol peak.
Higher dose levels may be used in animals with tumours responsive to corticosteroid therapy. In these cases, the dosage level is related to the surface area of the animal and dose levels of between 20 mg per m2 and 60 mg per m2 have been found to be useful. The potential risks associated with these high dose levels should be assessed before commencing treatment.
Prednidale 5 mg tablets for dogs and cats: The tablets are divisible.

Overdose
Signs of overdosage should be treated symptomatically.