Stronghold Plus for Cats is for cats with, or at risk from, mixed parasitic infestations by ticks and fleas, lice, mites, gastrointestinal nematodes or heartworm. It is exclusively indicated when use against ticks and one or more of the other target parasites is indicated at the same time.

Stronghold Plus has immediate and persistent flea killing activity against new infestations for 5 weeks. It also has immediate and persistent acaricidal effect for 5 weeks against Ixodes ricinus and Ixodes hexagonus, and 4 weeks against Dermacentor reticulatus and Rhipicephalus sanguineus.