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Nexgard

Nexgard Chewable Tablets are indicated for the treatment and prevention of flea and tick infestations on dogs, and can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD). The tablets contain an ingredient called Afoxolaner, which works by over-stimulating the nervous system of the flea and killing them before they have a chance to lay eggs.

Nexgard Tablets are presented as mottled red to reddish brown, circular shaped (Small Dog) or rectangular shaped tablets.

Nexgard 68mg Chewable Tablets for Large Dogs

Nexgard 68mg Chewable Tablets for Large Dogs

From:£20.12to…£35.82

Nexgard 68mg Chewable Tablets are indicated for the treatment and prevention flea and tick infestations on large breed dogs weighing >10-25kg. Nexgard contains an ingredient called...[More info]

From:£20.12to…£35.82
Nexgard 136mg Chewable Tablets for Extra Large Dogs

Nexgard 136mg Chewable Tablets for Extra Large Dogs

From:£23.62to…£41.93

Nexgard 136mg Chewable Tablets are indicated for the treatment and prevention flea and tick infestations on very large breed dogs weighing >25-50kg. Nexgard contains an ingredient called...[More info]

From:£23.62to…£41.93
Nexgard 28mg Chewable Tablets for Medium Dogs

Nexgard 28mg Chewable Tablets for Medium Dogs

From:£18.60to…£32.54

Nexgard 28mg Chewable Tablets are indicated for the treatment and prevention flea and tick infestations on medium breed dogs weighing >4-10kg. Nexgard contains an ingredient called...[More info]

From:£18.60to…£32.54
Nexgard 11mg Chewable Tablets for Small Dogs

Nexgard 11mg Chewable Tablets for Small Dogs

From:£16.86to…£30.19

Nexgard 11mg Chewable Tablets are indicated for the treatment and prevention flea and tick infestations on small breed dogs weighing 2-4kg. Nexgard contains an ingredient called Afoxolaner,...[More info]

From:£16.86to…£30.19

Indications for use
Treatment of flea infestation in dogs (Ctenocephalides felis and C. canis) for at least 5 weeks. The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).
Treatment of tick infestation in dogs (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus). One treatment kills ticks for up to one month.
Fleas and ticks must attach to the host and commence feeding in order to be exposed to the active substance.
Treatment of demodicosis (caused by Demodex canis).
Treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis).

Contra-indications
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

Special warnings for each target species
Parasites need to start feeding on the host to become exposed to afoxolaner; therefore the risk of the transmission of parasite borne diseases cannot be excluded.

Special precautions for use in animals
In the absence of available data, treatment of puppies less than 8 weeks of age and/or dogs less than 2 kg bodyweight should be based on a benefit-risk assessment by the responsible veterinarian.

Special precautions to be taken by the person administering the product to animals
To prevent children from getting access to the product, remove only one chewable tablet at a time from the blister. Return the blister with the remaining chewable tablets into the carton.
Wash hands after handling the product.

Adverse reactions
Mild gastrointestinal effects (vomiting, diarrhoea), pruritus, lethargy, or anorexia and neurological signs (convulsions, ataxia and muscle tremors) have been reported very rarely. Most reported adverse reactions were self-limiting and of short duration.
The frequency of adverse reactions is defined using the following convention:
• very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
• common (more than 1 but less than 10 animals in 100 animals)
• uncommon (more than 1 but less than 10 animals in 1,000 animals)
• rare (more than 1 but less than 10 animals in 10,000 animals)
• very rare (less than 1 animal in 10,000 animals, including isolated reports).

Use during pregnancy, lactation or lay
Laboratory studies in rats and rabbits have not produced any evidence of teratogenic effects, or any adverse effect on the reproductive capacity of males and females.
The safety of the veterinary medicinal product has not been established during pregnancy and lactation or in breeding dogs. Use only according to the benefit-risk assessment by the responsible veterinarian.
Interactions
None known.

Method of administration
The tablets are chewable and palatable to most dogs. If the dog does not accept the tablets directly they may be administered with food.
Treatment schedule:
Treatment of flea and tick infestations:
Monthly intervals throughout the flea and/or tick seasons, based on local epidemiological situations.
Treatment of demodicosis (caused by Demodex canis):
Monthly administration of the product until two negative skin scrapings are obtained one month apart. Severe cases may require prolonged monthly treatments. As demodicosis is a multi-factorial disease, where possible, it is advisable to also treat any underlying disease appropriately.
Treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis):
Monthly administration of the product for two consecutive months. Further monthly administration of the product may be required based on clinical assessment and skin scrapings.

Overdose
No adverse reactions were observed in healthy puppies over 8 weeks of age when treated with 5 times the maximum dose repeated 6 times at intervals of two to four weeks.

Pharmacodynamic properties
Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family. Afoxolaner acts at ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. The selective toxicity of afoxolaner between insect/acarines and mammals may be inferred by the differential sensitivity of the insect/acarines' GABA receptors versus mammalian receptors.
Afoxolaner is active against adult fleas as well as several tick species such as Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Rhipicephalus sanguineus, Amblyomma americanum and Haemaphysalis longicornis.
NexGard kills fleas within 8 hours and ticks within 48 hours.
The product kills fleas before egg production and therefore prevents household contamination.

Excipients
Maize starch, Soy protein fines, Braised beef flavouring, Povidone (E1201), Macrogol 400, Macrogol 4000, Macrogol 15 hydroxystearate, Glycerol (E422), Medium-chain triglycerides.

Major incompatibilities
Not applicable.