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Effipro contains fipronil - the leading spot on flea treatment for both cats and dogs. Each application of Effipro flea treatment kills both fleas and ticks. Effipro spot on should be applied to the skin on the back of your pets neck after parting the coat so that the skin is visible. Place the tip of the pipette directly against the bared skin and squeeze gently several times to empty its contents. It is important to make sure that the product is applied to an area where the animal cannot lick it off.