Nelio flavoured tablets are flavoured and may be taken spontaneously by dogs and cats, but can also be administered directly into the dog's/cat's mouth or be given with food if necessary.
Nelio contains benazepril which may cause mild, intermittent diarrhea in a small proportion of cats and dogs. In cats with chronic renal insufficiency, benazepril may increase plasma creatinine concentrations at the start of therapy. This effect is related to the therapeutic effect of the product in reducing blood pressure, and therefore is not necessarily a reason to stop therapy in the absence of other signs. Benazepril reduced erythrocyte counts in normal cats at high doses, but this effect was not observed at the recommended dose during clinical trials in cats with chronic renal insufficiency. As is routine in cases of chronic renal insufficiency, it is recommended to monitor erythrocyte counts during therapy.
Emesis, anorexia, dehydration and lethargy have been reported in rare occasions in some dogs and cats. Do not Nelio in case of known hypersensitivity to ACE inhibitors or to any ingredient of the product. Do not use in any dog that has evidence of cardiac output failure, for example, due to aortic stenosis
No evidence of renal toxicity to benazepril has been observed during clinical trials. However, as is routine in cases of renal insufficiency, it is recommended to monitor plasma urea and creatinine levels.
Laboratory studies in rats have shown embryotoxic effects of Benazepril at non-maternotoxic doses (urinary system abnormalities in foetus). Benazepril administered to cats at a daily dose of 10 mg / kg for 52 weeks resulted in the reduction of ovary / oviduct weights. Safety of this product has not been tested in pregnant or lactating queens. Do not use in pregnant or lactating females or in queens intended for breeding.
Blood pressure may be monitored during anesthesia in dogs and cats receiving benazepril.
Interactions with potassium preserving diuretics like spironolactone, triamterene or amiloride cannot be ruled out. It is recommended to monitor plasma potassium levels when using benazepril in combination with a potassium sparing diuretic as life threatening reactions are a possibility. Transient and reversible signs of hypotension may appear in case of accidental overdose. Treatment is symptomatic, involving intravenous infusion with warm isotonic saline.
No evidence of renal toxicity to benazepril has been observed in cats during clinical trials. However, as is routine in cases of renal insufficiency, it is recommended to monitor plasma urea and creatinine levels.
Efficacy and safety of benazepril have not been established in cats of weight less than 2.5 kg.mDo not store above 30°C. Store in original package. Any half-used tablet should be returned to the opened blister and used for the next administration. Keep out of reach of children.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. In dogs with heart failure, benazepril has been given in combination with digoxin, diuretics and anti-arrhythmic drugs without demonstrable adverse interactions.
Transient and reversible signs of hypotension may appear in case of accidental overdose. Treatment is symptomatic, involving intravenous infusion with warm isotonic saline. Morphologic changes such as hypertrophy or hyperplasia of juxtaglomerular cells, increase of uremia and a weight loss of the heart due to an involution have been observed with doses over 10 mg/kg in healthy dogs.
Special precautions to be taken by the person administering the veterinary medicinal product to animals:Pregnant women should take special care to avoid accidental oral exposure, because ACE inhibitors have been found to affect the unborn child during pregnancy in humans.
Wash hands after use. In case of accidental ingestion by children, seek medical advice immediately and show this label to the doctor.