Frontect Flea Treatments are indicated for the treatment and prevention of flea and/or tick infestations where repellent (anti-feeding) activity is necessary against sandflies, biting flies, and/or mosquitoes.
One treatment prevents new flea infestations for up to 4 weeks and can be used as part of a treatment strategy for flea allergy dermatitis.
The solution also has a repellent efficacy against ticks from 7 days and up to week 4 after treatment.
Do not use on sick or convalescent animals.
This product is for use on dogs only. Do not use in cats and rabbits, as adverse reactions and even death could occur.
Do not use in case of known hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
There may be an attachment of single ticks or bites by single mosquitoes or sandflies. For this reason, transmission of pathogens by these arthropods cannot be completely excluded if conditions are unfavorable.
The product remains effective against fleas when treated animals are immersed in water occasionally (e.g., swimming, bathing). However, dogs should not be allowed to swim or be shampooed within 48 hours after treatment. Avoid frequent swimming or shampooing of treated dogs as this may adversely affect maintenance of product effectiveness.
To reduce re-infestation from emergence of new fleas, it is recommended that all dogs in a household be treated. Other animals living in the same household should also be treated with a suitable product. To aid further in reducing environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developmental stages could be recommended.
Special precautions for use
i. Special precautions for use in animals
In the absence of specific studies, the use of the product is not recommended in dogs younger than 8 weeks of age, or in dogs weighing less than 2 kg.
Care should be taken to avoid contact of the veterinary medicinal product with dog’s eyes.
It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that other animals do not lick the treatment sites following application.
Due to the unique physiology of cats which prevents them from metabolizing certain compounds, including permethrin, the product can induce potentially fatal convulsions in this species. In case of accidental dermal exposure, wash the cat with shampoo or soap, and seek veterinary advice rapidly. To prevent cats from being accidentally exposed to the product, keep treated dogs away from cats until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog which has been treated with this product. In case of exposure of this type seek veterinary advice immediately.
ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals
This product can cause skin and eye irritation, therefore, avoid contact of the product with skin and eyes. Do not open the pipette near or towards the face. In case of ocular exposure or if eyes become irritated during administration, immediately flush the eyes with plenty of water. If ocular irritation persists, seek medical attention. In case of dermal exposure or if skin becomes irritated during administration, immediately wash the skin with plenty of soap and water. If skin irritation persists or recurs, seek medical attention.
People with known hypersensitivity to fipronil and/or permethrin should avoid contact with the product.
The product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat during application. Wash hands after use. If swallowed rinse mouth and seek medical attention if you feel unwell.
Since the excipient N-methylpyrrolidone may induce foetotoxicity and teratogenicity after significant exposure, pregnant women should wear gloves to avoid contact with the product.Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.
Keep the stored pipettes in the original blister and once used, the empty pipette should immediately be disposed of in a proper way, preventing further access.
iii. Other precaution
The product may adversely affect aquatic organisms. Treated dogs should not be allowed to enter surface water for 2 days after treatment.
Adverse reactions (frequency and seriousness)
Among the very rare suspected adverse reactions, transient skin reactions at the application site (skin discolouration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, hyperactivity, muscle tremor, depression, other nervous signs) or vomiting have also been observed after use.
If licking of the application site occurs, transient hypersalivation and emesis may be observed.
Use during pregnancy, lactation or lay
Laboratory studies using fipronil or permethrin have not shown any evidence of teratogenic or embryotoxic effects. Studies have not been carried out with this product in pregnant and lactating animals (see 4.5(i)).
N-methylpyrrolidone, an excipient in the veterinary medicinal product, has shown to be teratogenic in laboratory animals after repeated exposure at high doses.
Use only according to the benefit/risk assessment by the responsible veterinarian.
Interaction with other medicinal products and other forms of interaction