Frontline Combo for Large Dogs contains fipronil 268 mg, (S)-methoprene 241.20 mg, butylhydroxyanisole (E320) and butylhydroxytoluene (E321) in a pipette of 2.68ml solution.

Indicated to be used bi-monthly against infestations with fleas, and for the treatment of ticks and/or biting lice. Prevention of the multiplication of fleas by inhibiting the development of eggs, larvae and pupae originating from eggs laid by adult fleas for 6 weeks after application.