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Program Plus

Program Plus Tablets are indicated for the prevention of fleas (Ct. felis, Ct. canis, preadult stages), and for the concurrent prevention of heartworm (elimination of L3/L4 larval stages of Dirofilaria immitis) and/or treatment of adult stages of gastrointestinal nematodes such as hookworms (Ancylostoma caninum), roundworms (Toxocara canis) and whipworms (Trichuris vulpis)

Program Plus Tablets contain the active ingredients Milbemycin Oxime and Lufenuron, and are presented as white, pentagonal, biconvex, bevel-edged and film-coated tablets.

Program Plus 460mg Tablets for Large Dogs (White)

Program Plus 460mg Tablets for Large Dogs (White)

£41.10

Program Plus 460mg Tablets are indicated for the prevention of flea infestations and for the concurrent prevention of heartworm disease in dogs weighing 23-45kg. Program Plus can also be...[More info]

£41.10
Program Plus 115mg Tablets for Small Dogs (Green)

Program Plus 115mg Tablets for Small Dogs (Green)

£37.64

Program Plus 115mg Tablets are indicated for the prevention of flea infestations and for the concurrent prevention of heartworm disease in dogs weighing 5-11kg. Program Plus can also be...[More info]

£37.64
Program Plus 230mg Tablets for Medium Dogs (Yellow)

Program Plus 230mg Tablets for Medium Dogs (Yellow)

£38.56

Program Plus 230mg Tablets are indicated for the prevention of flea infestations and for the concurrent prevention of heartworm disease in dogs weighing 12-22kg. Program Plus can also be...[More info]

£38.56

Contraindications
Do not use in case of hypersensitivity to the active substance, to the adjuvants or to any of the excipients.

Special warnings
Ideally, tablets are administered on the same day each month. If an interval is greater than 6 weeks, treatment should be resumed immediately and be continued at monthly intervals and, in case of heartworm prevention, a veterinarian should be consulted.

Special precautions for use in animals
In heartworm risk regions, or in case it is known that a dog has been travelling to and from heartworm risk regions, before commencing PROGRAM Plus treatment as with any other heartworm preventive,
a veterinary consultation is advised to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated before administering PROGRAM Plus.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
None.
In the case of accidental ingestion seek medical advice immediately and show the package leaflet or the label to the physician.

Adverse reactions (frequency and seriousness)
Pale mucous membranes, increased intestinal peristalsis, lethargy, diarrhoea have been observed very rarely after treatment. The treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of moderate and transitory hypersensitivity reactions, such as pale mucous membranes, vomiting, laboured breathing, or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product.

Use during pregnancy, lactation or lay
Pregnancy:
Can be used during pregnancy.
Lactation:
Can be used during lactation.

Interaction with other medicinal products and other forms of interaction
During treatment with PROGRAM Plus, no other antiparasitic macrocyclic lactones should be administered.

Amounts to be administered and administration route
PROGRAM Plus tablets, available in four sizes, are given according to the weight of the dog, consistent with the administration of a minimum dose of 0.5 mg milbemycin oxime and 10 mg lufenuron per kg body weight.

PROGRAM Plus should be administered in the following situations:
Puppies:
To prevent flea infestations with concurrent heartworm prevention and/or gastrointestinal nematode infection treatment should start from 2 weeks of age, or from a minimum weight of 1 kg.
Dogs in a non-heartworm region:
Program Plus can be used as part of the seasonal prevention of fleas replacing lufenuron mono (PROGRAM tablets) in cases with diagnosed concurrent gastrointestinal nematode infection. After elimination of the nematode infection confirmed by faecal examination, prevention of fleas should continue with PROGRAM tablets if indicated.
In puppies, treatment with Program Plus is recommended up to one month after weaning. Thereafter, prevention of fleas can be continued with lufenuron mono (Program).
Dogs travelling to a heartworm region:
To prevent flea infestations with concurrent heartworm prevention, dogs travelling to a heartworm risk region should begin medication within one month after arrival. Treatment should continue monthly, with the last administration given after the dog has left the region.
Dogs in a heartworm region:
To prevent flea infestations and to prevent heartworm, medication should begin within one month after the appearance of mosquitoes, or one month before the appearance of fleas, and continue throughout the risk period with the last dose given within one month after the mosquito and flea season finishes.
If dogs have a high level of flea infestation at the start of treatment, it may be necessary to apply a flea adulticide during the first one to two months. It is important to treat all dogs and cats in the household for fleas. Cats in the same household should be treated with PROGRAM oral or injectable suspension.

Overdose (symptoms, emergency procedures, antidotes), if necessary
At 10x recommended dose rate (i.e. 5 mg milbemycin oxime, 100 mg lufenuron per kg) and higher dose rates clinical signs such as transient ataxia, trembling, depression, salivation, and mydriasis may be observed. There is no specific antidote.

Withdrawal period(s)
Not applicable.

Pharmaceutical particulars
List of excipients
Titanium dioxide (E171)
Macrogol 8000
Cellulose, microcrystalline
Lactose monohydrate
Pregelatinized maize starch
Croscarmellose sodium
Hypromellose
Talc
Magnesium stearate