Corvental

Corvental D Capsules for Dogs are the treatment of bronchitis and congestive heart failure in dogs. The active ingredient works to quickly dilate coronary arteries and relieve broncho-spasms, which enables the heart to function with greater efficiency, and provide oxygen and nutrition to internal organs more easily.

Corvental Capsules are presented as hard, opaque capsules with either Th100, Th200, or Th500 printed onto them depending on the strength of the active ingredient.

Contraindications

Concurrent use of beta-sympathomimetics is contra-indicated, as additive or synergistic interactions, resulting in exaggerated side effects may result. Do not use in dogs with a known history of epileptiform seizures as convulsions have been reported in patients on theophylline treatment, often with no preceding signs of toxicity and in otherwise apparently normal animals.

Special Warnings for Each Target Species

None known.

Special Precautions for Use in Animals

Theophylline should be used with caution in patients with liver disease. If vomiting occurs, the dose should be reduced, or the treatment discontinued.

Special Precautions to be Taken by the Person Administering the Veterinary Medicinal Product to Animals

In the case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.

Adverse Reactions (Frequency and Seriousness)

The following side effects have been reported: restlessness, agitation, excitement, vomiting, diarrhoea, polydipsia, sedation, reduced appetite, and polyuria. If signs of CNS excitement occur, (twitching, restlessness, or convulsions) discontinue treatment immediately.

Use During Pregnancy, Lactation or Lay

When theophylline is prescribed to pregnant bitches, the risk-benefit of the treatment should be assessed. Only small amounts of theophylline are excreted in milk.

Interaction with Other Medicinal Products and Other Forms of Interaction

Plasma theophylline levels may increase in patients under treatment with macrolide and fluoroquinolone antibiotics, such as erythromycin and enrofloxacin, and decrease in patients receiving phenobarbitone or phenytoin.
Theophylline may reduce the convulsive threshold in patients receiving ketamine.
Administration of theophylline shortly before halothane anaesthesia may result in arrhythmogenic effects.

Amounts to be Administered and Administration Route

20mg per kg bodyweight to be given orally once daily only.
Care should be taken to ensure that dogs are weighed carefully and accurately, and the dose does not exceed 20mg/kg body weight.

Overdose (Symptoms, Emergency Procedures, Antidotes), if Necessary

There is no specific treatment for theophylline overdose in the dog. The condition should be treated symptomatically with emetics, oral activated charcoal, or anti-convulsive drugs as necessary.

Withdrawal Period(s)

Not applicable.