Clindaseptin is for the treatment of infected wounds, abscesses, superficial pyoderma and oral cavity/dental infections caused by or associated with clindamycin-sensitive staphylococci, streptococci, bacteroidaceae, Fusobacterium necrophorum, Clostridium perfringens and osteomyelitis caused by Staphylococcus aureus. They can also be used to help provide antimicrobial cover during dental procedures.
Clindaseptin is available in a colourless oral solution suitable for both cats and dogs, and as hard capsules suitable for dogs.
Contra-indications, warnings, etc
Do not administer to animals with hypersensitivity to clindamycin or lincomycin.
Do not administer to rabbits, hamsters, guinea pigs, chinchillas, horses or ruminants because ingestion of clindamycin by these species may result in severe gastro-intestinal disturbance.
Before use of Clindaseptin capsules, the identification of causative pathogenic micro-organisms should be carried out and their susceptibility to clindamycin should be established.
Clindamycin and lincomycin show parallel resistance. There is a partial cross-resistance to erythromycin and other macrolide antibiotics.
Special precautions for use in animals
During prolonged therapy of one month or greater, periodic liver and kidney function tests and blood counts should be performed. Patients with severe renal and/or hepatic disturbances accompanied by severe metabolic aberrations should be dosed with caution and should be monitored by serum examination during high dose clindamycin therapy.
Whenever possible, the veterinary medicinal product should only be used based on susceptibility testing.
Adverse reactions (frequency and seriousness)
Vomiting and diarrhoea are observed occasionally. Clindamycin sometimes causes the overgrowth of non-sensitive organisms such as resistant clostridia and yeasts. In cases of superinfection, appropriate measures should be taken according to the clinical situation.
Use during pregnancy and lactation
While high dose studies in rats suggests that clindamycin is not a teratogen and does not significantly affect the breeding performance of males and females, safety during pregnancy and lactation or in breeding male dogs has not been established. Therefore, the administration of the veterinary medicinal product during pregnancy and lactation should be the subject of a benefit/risk assessment by the veterinarian.
Interaction with other medicinal products and other forms of interaction
Neuromuscular blocking effects have been observed with clindamycin possibly leading to an increase of efficacy of other neuromuscular blocking agents. The concomitant use of such drugs must be handled with care.
Clindamycin should not be used concomitantly with chloramphenicol or macrolides because they may antagonise each other at the site of action.
Those with known hypersensitivity to lincosamides (lincomycin, clindamycin) should not handle the product. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the Doctor this warning. Swelling of the face, lips or eyes, or breathing difficulties are more serious symptoms and require urgent medical attention. Accidental ingestion of this product may cause transient gastrointestinal effects, and so should be avoided. If a child accidentally consumes this product, seek medical advice.
Symptoms of overdose include vomiting, inappetence and diarrhoea. In such cases, treatment should be stopped immediately and the dogs treated symptomatically.