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I used this when we first got Roxie as a very nervous rescue dog and it had some effect. I purchased again in advance of Halloween and fireworks together with an Adaptil diffuser. The difference this year was amazing. Very much calmer and less distressed. Previously following fireworks it was impossible to get her to come out for a walk for some days afterwards but this time she came out each morning without a problem.
Some calmer behaviour noted for my dog whilst I was in the house, still greeted me with as much anxiety when I got home. Definitely would work in conjunction with behaviour modification to enable the dog to be more open to therapy.