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Prednicare

Prednicare is indicated as an anti-inflammatory and anti-allergic agent for use in cats and dogs.

Prednicare contains the active ingredient Prednisolone. Prednisolone is a corticosteroid known as a glucocorticoid. Corticosteroids act on the immune system by blocking the production of substances that trigger inflammatory and immune responses.

Prednicare is normally administered once or twice daily, although for longer treatment courses, it is sometimes given on alternate days. Although known to be almost as effective as dosing every day, it is less likely to be associated with known side effects.

Prednicare Tablet 1mg

Prednicare Tablet 1mg

£0.05

Prednicare (Prednisolone) 1mg tablet is indicated as an anti-allergic, anti-inflammatory agent for use in dogs and cats. Prednicare contains 1mg of Prednisolone as its active ingredient....[More info]

£0.05
Prednicare Tablet 5mg

Prednicare Tablet 5mg

£0.04

Prednicare (Prednisolone) 5mg tablet is indicated as an anti-allergic, anti-inflammatory agent for use in dogs and cats. Prednicare contains 5mg of Prednisolone as its active ingredient....[More info]

£0.04

Contraindications:
Systemic corticosteroid therapy is generally contra-indicated in patients with renal disease or diabetes mellitus. Administration is contra-indicated where corneal ulceration is present. The use of corticosteroids may render vaccinations inoperative. Administration in late pregnancy may cause early parturition and abortion.

Special warnings for each target species:
Dosing should coincide with the endogenous cortisol peak (i.e., in the morning with regard to dogs and in the evening with regard to cats).

Special precautions for use:
i. Special precautions for use in animals Caution is necessary when prescribing corticosteroids in animals with the following conditions: epilepsy; glaucoma; hypertension; osteoporosis; peptic ulceration; previous steroid myopathy.
ii. Special precautions for the person administering the veterinary medicinal product to animals Impermeable gloves should be worn whilst administering the product. Wash hands thoroughly with soap and water after handling this product. In case of accidental ingestion, drink plenty of water and seek medical advice.
iii. Other precautions None

Adverse reactions (frequency and seriousness):
Anti-inflammatory steroids, such as prednisolone, are known to exert a wide range of side-effects. Whilst single high doses are generally well tolerated, they may induce severe side-effects in long-term use and when esters possessing a long duration of action are administered. Dosage in medium to long term should therefore generally be kept to the minimum necessary to control symptoms. Steroids themselves, during treatment, may cause Cushingoid symptoms involving significant alteration of fat, carbohydrate, protein and mineral metabolism, e.g., redistribution of body fat, muscle weakness and osteoporosis may result.
During therapy, effective doses suppress the Hypothalamo-Pituitreal-Adrenal axis. Following cessation of treatment, symptoms of adrenal insufficiency extending to adrenocorticol atrophy can arise and this may render the animal unable to deal adequately with stressful situations. Consideration should therefore be given to means of minimising problems of adrenal insufficiency following the withdrawal of treatment, e.g., dosing on alternate days, dosing to coincide with the endogenous cortisol peak (i.e., in the morning with regard to dogs and in the evening with regard to cats) and a gradual reduction in dosage (for further discussion see standard texts).
Systemically acting corticosteroids may cause polyuria, polydipsia and polyphagia, particularly during the early stages of therapy. Some corticosteroids may cause sodium and water retention and hypokalaemia in long term use. Systemic corticosteroids have caused deposition of calcium in the skin (calcinosis cutis).
Corticosteroids are not recommended for use in pregnant animals. Administration in early pregnancy is known to have caused foetal abnormalities in laboratory animals. Administration in late pregnancy may cause early parturition or abortion.
Corticosteroids may delay wound healing and the immunosuppressant actions may weaken resistance to or exacerbate existing infections. In the presence of bacterial infection, anti-bacterial drug cover is usually required when steroids are used. In the presence of viral infections, steroids may worsen or hasten the progress of the disease.
Gastrointestinal ulceration has been reported in animals treated with corticosteroids and g.i.t. ulceration may be exacerbated by steroids in patients given non-steroidal anti-inflammatory drugs and in corticosteroid treated animals with spinal cord trauma.
Steroids may cause enlargement of the liver (hepatomegaly) with increased serum hepatic enzymes.

Use during pregnancy, lactation or lay:
Corticosteroids are not recommended for use in pregnant animals. Administration in early pregnancy is known to have caused foetal abnormalities in laboratory animals. Administration in late pregnancy may cause early parturition or abortion.