Galastop Oral Solution is for the treatment of false pregnancy and the suppression of lactation in bitches. The solution is a pale yellow, viscous non aqueous solution for oral administration containing 50 µg/ml cabergoline in a miglyol base. Galatop Oral Solution can be administered directly into the mouth or by mixing with food and is available in 2 different sizes: 7ml and 15ml.
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Galastop Oral Solution 7ml is for the treatment of false pregnancy and the suppression of lactation in bitches. The solution is a pale yellow, viscous non aqueous solution for oral... [More info]
Galastop Oral Solution 15ml is for the treatment of false pregnancy and the suppression of lactation in bitches. The solution is a pale yellow, viscous non aqueous solution for oral... [More info]
Cabergoline is an ergoline derivative with a potent, selective and long-lasting inhibitory effect on prolactin secretion. Prolactin is the key hormone for lactogenesis and for the initiation and maintenance of lactation after parturition. Furthermore the aetiology of false pregnancy is currently thought to be mediated by rising prolactin levels stimulated by falling progesterone levels during the course of metoestrus.
Treatment of false pregnancy in bitches
Inhibition of prolactin secretion by cabergoline results in a rapid resolution of the signs of false pregnancy, including lactation and behavioural changes.
Suppression of lactation in bitches
Suppression of lactation in the bitch may be required under certain clinical circumstances (for example following removal of puppies soon after birth, or following early weaning). Inhibition of prolactin secretion by Galastop® results in a rapid cessation of lactation and a reduction in the size of the mammary glands.
Dosage and administration
Galastop® should be administered orally either directly into the mouth or by mixing with food.
The dosage is 0.1 ml/kg bodyweight (equivalent to 5 μg/kg body weight of cabergoline) once daily for 4-6 consecutive days, depending on the severity of the clinical condition.
For dogs less that 5 kg bodyweight it is advisable to measure the dosage in drops, 3 drops being equivalent to 0.1 ml.
If the signs fail to resolve after a single course of treatment, or if they recur after the end of treatment, then the course of treatment may be repeated.
For treatment of false pregnancy, clinical studies have demonstrated efficacy between 80-100%. Behavioural signs are alleviated first, followed by reduction in mammary gland enlargement, then finally suppression of lactation.
Contra-indications, warnings, etc
Do not use in pregnant animals since Galastop® may cause abortion. Do not use in lactating bitches unless suppression of lactation is required.
Galastop® may induce transient hypotension in treated animals. Do not use in animals concurrently being treated with hypotensive drugs. Do not use directly after surgery whilst the animal is still under the influence of the anaesthetic agents. Additional supportive treatments should involve restriction of water and carbohydrate intake and increase exercise.
Since cabergoline exerts its therapeutic effect by direct stimulation of dopamine receptors, Galastop® should not be administered concurrently with drugs which have dopamine antagonist activity (such as phenothiazines, butyrophenones), as these might reduce its prolactin inhibiting effects.
Vomiting or anorexia may occur after the first one or two doses in a small proportion of cases. There is no need to discontinue treatment unless vomiting is severe or it persists beyond the second dose.
In some animals a degree of drowsiness may be seen in the first 2 days of dosing.
The experimental data indicate that a single overdose with Galastop® might result in an increased likelihood of post-treatment vomiting, and possibly an increase in post-treatment hypotension. General supportive measures should be undertaken to remove any unabsorbed drug and maintain blood pressure, if necessary. It is unlikely that the administration of dopamine antagonist drugs would be necessary, but this course of action could be considered.
Special precautions to be taken by the person administering the medicinal product to animals
Wash hand after use. Avoid contact with skin and eyes wash of any splashes immediately. Care should be taken to avoid contact between the solution and women of childbearing age. Women of childbearing age should wear gloves when administering the product.
For animal treatment only. Keep out of reach and sight of children.
Amber type III glass bottle with screw cap, containing 7 ml or 15 ml 0.005% cabergoline oily solution; supplied with a clear type I glass pipette (graduated dropper) with protective cover.
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