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Clomicalm

Clomicalm is available in divisible, flavoured tablets of 3 dosage strengths: Clomicalm 5mg, Clomicalm 20mg, and Clomicalm 80mg. Clomicalm can be used as an aid in the treatment of separation-related disorders in dogs manifested by destruction and inappropriate elimination (defecation and urination) and only in combination with behavioural modification techniques.

Clomicalm 20mg Tablets

Clomicalm 20mg Tablets

£1.92

Clomicalm tablets contain Clomipramine hydrochloride. Indicated as an aid in the treatment of separation-related disorders in dogs manifested by destruction and inappropriate elimination...[More info]

£1.92
Clomicalm 5mg Tablets

Clomicalm 5mg Tablets

£1.61

Clomicalm tablets contain Clomipramine hydrochloride. Indicated as an aid in the treatment of separation-related disorders in dogs manifested by destruction and inappropriate elimination...[More info]

£1.61
Clomicalm 80mg Tablets

Clomicalm 80mg Tablets

£3.67

Clomicalm tablets contain Clomipramine hydrochloride. Indicated as an aid in the treatment of separation-related disorders in dogs manifested by destruction and inappropriate elimination...[More info]

£3.67

Clomicalm is given orally with or without food. In clinical trials, a treatment time of 2-3 months with Clomicalm in combination with behavioural modification techniques was sufficient to control the symptoms of separation-related disorders. Some cases may require longer treatment. In cases showing no improvement after 2 months, treatment with Clomicalm should be ceased.

Known hypersensitivity to clomipramine and related tricyclic antidepressants. Do not use in male breeding dogs.

Clomicalm may very rarely cause vomiting, changes in appetite, lethargy or an elevation in liver enzymes, which is reversible when the product is discontinued. Hepato-biliary disease has been reported, especially with pre-existing conditions, and concurrent administrations of drugs metabolised via the hepatic system. Vomiting may be reduced by co-administration with a small quantity of food. If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.

Dog: It is recommended that Clomicalm be administered to dogs with cardiovascular dysfunction or epilepsy with caution and only after an assessment of the benefit/risk ratio. Because of its potential anticholinergic properties, Clomicalm should also be used with care in dogs with narrow angle glaucoma, reduced gastrointestinal motility or urinary retention. Clomicalm should be used under veterinary supervision. The efficacy and safety of Clomicalm has not been established in dogs weighing less than 1.25kg or under 6 months of age.

Persons administering the product: In children, accidental ingestion should be regarded as serious. There is no specific antidote. In case of accidental ingestion, seek medical advice immediately and show the product label to the physician. Overdose in human beings causes anticholinergic effects although central nervous and cardiovascular systems may also be affected. People with known hypersensitivity to clomipramine should administer the product with caution.

Use during pregnancy and lactation: The safety of the veterinary medicinal product has not been established in female dogs during pregnancy and lactation. Laboratory animal studies in mice and rats have shown evidence of embryotoxic effects.

Interaction with other medicaments: Recommendations on the interaction between Clomicalm and other medicaments are derived from studies in species other than dogs. Clomicalm may increase the effects of the anti-arrhythmic drug quinidine, anticholinergic agents (e.g. atropine), other CNS active drugs (e.g. barbiturates, benzodiazepines, general anaesthetics, neuroleptics), sympathomimetics (e.g. adrenaline) and coumarine derivatives. The administration of Clomicalm is not recommended in combination with, or within 2 weeks of therapy with, monoamine oxidase inhibitors. Simultaneous administration with cimetidine may lead to increased plasma levels of clomipramine. Plasma levels of certain anti-epileptic drugs, such as phenytoin and carbamazepine, may be increased by coadministration with Clomicalm.

Overdose: At overdose with 20mg/kg Clomicalm (5 times the maximum therapeutic dose), bradycardia and arrhythmias (atrioventricular node block and ventricular escape beats) were observed approximately 12 hours after dosing. Overdose with 40mg/kg (20 times the recommended dose) of Clomicalm produced hunched posture, tremors, flushed abdomen and decreased activity in dogs. Higher doses (500mg/kg i.e. 250 times the recommended dose) produced emesis, defecation, drooped eyes, trembling and quietness. Still higher doses (725mg/kg) produced, in addition, convulsions and death.

Environmental precautions: Any unused veterinary medicinal products or waste material derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Store Clomicalm flavoured tablets in the original container. Keep out of reach and sight of children. Accidental ingestion should be regarded as serious.

Each tablet size is supplied in plastic bottles containing 30 tablets (with desiccant).

For animal treatment only. Keep out of reach and sight of children. For any information about this veterinary medicinal product, please contact the local representative of the Marketing Authorisation Holder.