Frontline Combo Extra Large for Dogs contains fipronil 402 mg, (S)-methoprene 361.80 mg, butylhydroxyanisole (E320) and butylhydroxytoluene (E321) in a pipette of 4.02ml solution.

Indicated to be used bi-monthly against infestations with fleas, and for the treatment of ticks and/or biting lice. Prevention of the multiplication of fleas by inhibiting the development of eggs, larvae and pupae originating from eggs laid by adult fleas for 6 weeks after application.