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I have been using this product for 2 years or so now on both of my dogs (GSD & Smooth Collie) and have not encountered any problems whatsoever. I dose both of my dogs with 1 Pipette every 8 weeks and find this frequency quite sufficient. I used to use Frontline but like for like this product is just as good and considerably cheaper.
Don't waste your money, if I could I would have given this zero stars. Made absolutely no difference to either of our dogs. In fact the fleas got worse after treatment. Worst product I have ever used. A waste of money.
Got this for my dog for the first time it has worked brilliantly especially the way she likes to run through long grass !